Organic Synthesis Laboratory

Standards for metabolic research

Quantification of metabolites in body fluids by stable isotope dilution GC-MS or LC-MS/MS provides a reliable approach to the diagnoses of many inherited metabolic disorders . It requires the availability of the original compounds for establishing calibration curves, and of stable isotopically labelled analogs of the analites for use as internal standards. Ordinary compounds are obtainable from industrial suppliers, the less common compounds have been home-made by chemical synthesis.

For more information contact:

Organic Synthesis Laboratory

organic.synthesis.lab@amsterdamumc.nl

Amsterdam UMC, location VUmc