Agtmael, Michiel van

Name: Dr. Michiel van Agtmael
Title: Internist, Clinical pharmacologist, Infectious diseases specialist
Position: Head of section Pharmacotherapy, Dept. internal medicine, VUmc

Short introduction

Since 1994, Michiel does academic work (AMC, Erasmus MC, since 2001 VUmc) with mix of clinical work, teaching and research. He has a long clinical experience in the care for patients with infectious diseases. Since 2013, he is the head of the section Pharmacotherapy with a focus on education and research in education.Course member in course in teaching leadership (CEUT Center of Excellence in University Teaching)

Research interests

  • Mainly in therapy, antimicrobial, HIV.
  • Recent focus on therapeutic reasoning and how to teach pharmacotherapy to students and doctors


Journals on Medical Education

  • De opleiding tot medisch microbioloog in 2020. M.A. van Agtmael. Nederlands Tijdschrift voor Medische Microbiologie. Augustus 2003. 80-82

Journals on Infectious Diseases


  • 1392 (345 eerste auteur, 1027 co- of laatste auteur) citaties gebaseeerd op 52 (S)SCI publicaties. H-index=20. 
  • Using a dog's superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study. Bomers MK, van Agtmael MA, Luik H, van Veen MC, Vandenbroucke-Grauls CM, Smulders YM. BMJ. 2012 Dec 13;345:e7396. doi: 10.1136/bmj.e7396.
  • Zidovudine/lamivudine but not nevirapine in combination with lopinavir/ritonavir decreases subcutaneous adipose tissue mitochondrial DNA. Feeney ER, van Vonderen MG, Wit F, Danner SA, van Agtmael MA, Villarroya F, Domingo P, Capeau J, Reiss P, Mallon PW; MEDICLAS, NECATT study groups. AIDS. 2012 Nov 13;26(17):2165-74.
  • Liraglutide treatment in a patient with HIV and uncontrolled insulin-treated type 2 diabetes. Diamant M, van Agtmael M. Diabetes Care. 2012 May;35(5):e34.
  • The lopinavir/ritonavir-associated rise in lipids is not related to lopinavir or ritonavir plasma concentration. Bierman WF, van Vonderen MG, Veldkamp AI, Burger DM, Danner SA, Reiss P, van Agtmael MA. Antivir Ther. 2011;16(5):647-55.
  • Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.
    Bierman WF,Scheffer GL, Schoonderwoerd A, Jansen G, van Agtmael MA, Danner SA, Scheper RJ. J Antimicrob Chemother. 2010 Aug;65(8):1672-80.
  • Tryps after adventurous trips. Claessen FA, Blaauw GJ, van der Vorst MJ, Ang CW, van Agtmael MA. Neth J Med. 2010 Mar;68(3):144-5.
  • Incomplete reversibility of tenofovir-related renal toxicity in HIV-infected men. Wever K, van Agtmael MA, Carr A. J Acquir Immune Defic Syndr. 2010 Sep 1;55(1):78-81.
  • Insulin sensitivity in multiple pathways is differently affected during zidovudine/lamivudine-containing compared with NRTI-sparing combination antiretroviral therapy. van Vonderen MG, Blümer RM, Hassink EA, Sutinen J, Ackermans MT, van Agtmael MA, Yki-Jarvinen H, Danner SA, Serlie MJ, Sauerwein HP, Reiss P. J Acquir Immune Defic Syndr. 2010 Feb 1;53(2):186-93.
  • Insulin Sensitivity in Multiple Pathways is Differently Affected During Zidovudine/Lamivudine-Containing Compared With NRTI-Sparing Combination Antiretroviral Therapy. van Vonderen MG, Blümer RM, Hassink EA, Sutinen J, Ackermans MT, van Agtmael MA, Yki-Jarvinen H, Danner SA, Serlie MJ, Sauerwein HP, Reiss P. J Acquir Immune Defic Syndr.2010 Feb;53(2):186-93.
  • Bone hydatid disease refractory to nitazoxanide treatment. Schipper HG, Simsek S, van Agtmael MA, van Lienden KP. Am J Trop Med Hyg. 2009 Sep;81(3):446-8.
  • Streptococcus pneumoniae DNA load in blood as a marker of infection in patients with community-acquired pneumonia. Peters RP, de Boer RF, Schuurman T, Gierveld S, Kooistra-Smid M, van Agtmael MA, Vandenbroucke-Grauls CM, Persoons MC, Savelkoul PH. J Clin Microbiol. 2009 Oct;47(10):3308-12.
  • Non-responsiveness to hepatitis B vaccination in HIV seropositive patients; possible causes and solutions. van den Berg R, van Hoogstraten I, van Agtmael M. AIDS Rev. 2009 Jul-Sep;11(3):157-64.
  • Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V. Nijhuis M, Wensing AM, Bierman WF, de Jong D, Kagan R, Fun A, Jaspers CA, Schurink KA, van Agtmael MA, Boucher CA. J Infect Dis. 2009 Sep 1;200(5):698-709.
  • Zidovudine/lamivudine for HIV-1 infection contributes to limb fat loss. van Vonderen MG, van Agtmael MA, Hassink EA, Milinkovic A, Brinkman K, Geerlings SE, Ristola M, van Eeden A, Danner SA, Reiss P; MEDICLAS study group. PLoS One. 2009 May 21;4(5):e5647.
  • First line zidovudine/lamivudine/lopinavir/ritonavir leads to greater bone loss compared to nevirapine/lopinavir/ritonavir. van Vonderen MG, Lips P, van Agtmael MA, Hassink EA, Brinkman K, Geerlings SE, Sutinen J, Ristola M, Danner SA, Reiss P. AIDS. 2009 Jul 17;23(11):1367-76.
  • Carotid Intima-Media Thickness and Arterial Stiffness in HIV-Infected Patients: The Role of HIV, Antiretroviral Therapy, and Lipodystrophy. van Vonderen MG, Smulders YM, Stehouwer CD, Danner SA, Gundy CM, Vos F, Reiss P, van Agtmael MA. J Acquir Immune Defic  Syndr. 2009 Feb;50(2):153-161.
  • Increase in carotid artery intima-media thickness and arterial stiffness but improvement in several markers of endothelial function after initiation of antiretroviral therapy. van Vonderen MG, Hassink EA, van Agtmael MA, Stehouwer CD, Danner SA, Reiss P, Smulders Y. J Infect Dis. 2009 Apr 15;199(8):1186-94.
  • HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review. Bierman WF, van Agtmael MA, Nijhuis M, Danner SA, Boucher CA. AIDS. 2009 Jan 28;23(3):279-91.
  • Rapid detection of microbial infection in the ICU: An ongoing search for new diagnostic tools.
    Peters R.P.H., Savelkoul P.H.M., Vandenbroucke-Grauls C.M.J.E, van Agtmael M.A., Simoons-Smit A.M.  Netherlands Journal of Critical Care 2009 13:1 (23-30)
  • Mycoplasma pneumoniae infection with incomplete Stevens-Johnson syndrome. Hillebrand-Haverkort ME, Budding AE, bij de Vaate LA, van Agtmael MA. Lancet Infect Dis. 2008 Oct;8(10):586-7.
  • 5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors. Kortmann W, van Agtmael MA, van Diessen J, Kanen BL, Jakobs C, Nanayakkara PW. Neth J Med. 2008 Sep;66(8):354-7.
  • Lymphogranuloma venereum diagnostics: from culture to real-time quadriplex polymerase chain reaction. Morré SA, Ouburg S, van Agtmael MA, de Vries HJ. Sex Transm Infect. 2008 Aug;84(4):252-3.
  • Zidovudine/lamivudine contributes to insulin resistance within 3 months of starting combination antiretroviral therapy. Blümer RM, van Vonderen MG, Sutinen J, Hassink E, Ackermans M, van Agtmael MA, Yki-Jarvinen H, Danner SA, Reiss P, Sauerwein HP. AIDS. 2008 Jan 11;22(2):227-36.
  • Targets of anticytokine therapy and the risk of infections in humans and mice. van de Vosse E, van Agtmael MA. Curr Opin Rheumatol. 2007 Nov;19(6):626-35.
  • Quantitative detection os Staphylococcus aureus and Enterococcus Faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit. Peters RP, van Agtmael MA, Gierveld S, Danner SA, Groeneveld AB, Vandenbroucke-Grauls CM, Savelkoul PH. J Clin Microbiol. 2007 Sep 19; 2007 Nov;45(11):3641-6.
  • Whipple's disease in mentally retarded patients: Report of two cases. Pettersson A, Van Winsen L, Van Oosten B, Kramers C, Van De Ven A, Savelkoul P, Van Agtmael M. Scand J Infect Dis. 2007 Jun 21;:1-3.
  • Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice. de Steenwinkel JE, van Vianen W, Ten Kate MT, Verbrugh HA, van Agtmael MA, Schiffelers RM, Bakker-Woudenberg IA. J Antimicrob Chemother. 2007 Nov;60(5):1064-73.
  • Increase in HCV incidence among men who have sex with men in Amsterdam most likely caused by sexual transmission. van de Laar TJ, van der Bij AK, Prins M, Bruisten SM, Brinkman K, Ruys TA, van der Meer JT, de Vries HJ, Mulder JW, van Agtmael M, Jurriaans S, Wolthers KC, Coutinho RA. J Infect Dis. 2007 Jul 15;196(2):230-8.
  • Fatal Salmonella enteritidis septicaemia in a rheumatoid arthritis patient treated with a TNF-alpha antagonist. Rijkeboer A, Voskuyl A, Van Agtmael M. Scand J Infect Dis. 2007;39(1):80-3.
  • New developments in the diagnosis of bloodstream infections. Peters RP, van Agtmael MA, Danner SA, Savelkoul PH, Vandenbroucke-Grauls CM. Lancet Infect Dis. 2004 Dec;4(12):751-60.
  • Progression of HIV to AIDS: a protective role for HLA-B27? den Uyl D, van der Horst-Bruinsma IE, van Agtmael M. AIDS Rev. 2004 Apr-Jun;6(2):89-96.
  • Markers of microbial infection. ABJ Groeneveld, A Tacx, RP Peters, MA van Agtmael, CE Hack. Advances in Sepsis Vol 3 (3), 2004; 83-90
  • Artemisinin drugs in the treatment of malaria. M.A. van Agtmael, T.A.Eggelte, C.J. van Boxtel.Trends in Pharmacological Sciences, May 1999; 20 (5): 199-205
  • Acute Chest Syndrome in Adult Afro Caribbean Patients With Sickle Cell Disease. Analysis of 81 episodes among 53 patients. Michiel A. van Agtmael, Johnny D. Cheng, Hans C. Nossent. Archives of Internal Medicine Vol 154, Mar 1994; 557 561.
  • Successful treatment of a disseminated Nocardia brasiliensis infection. Smeets LC, van Agtmael MA, van der Vorm ER. Eur J Clin Microbiol Infect Dis. 2005 May;24(5):350-1.
  • Persistent fever in a patient with Salmonella typhimurium gonarthritis. Becker A, van Agtmael MA, Comans EF, Voskuyl AE. Ned Tijdschr Geneeskd. 2005 Jan 1;149(1):33-6.
  • Fulminant ocular leishmaniasis in an HIV-1-positive patient. Meenken C, van Agtmael MA, Ten Kate RW, van den Horn GJ. AIDS. 2004 Jul 2;18(10):1485-6.
  • A case of legionellosis during treatment with a TNFalpha antagonist. Wondergem MJ, Voskuyl AE, van Agtmael MA. Scand J Infect Dis. 2004;36(4):310-1.
  • Stomach ache and fever after consumption of watercress in Turkey: fascioliasis. van Daele PL, Madretsma GS, van Agtmael MA. Ned Tijdschr Geneeskd. 2001 Sep 29;145(39):1896-9.
  • A most unfortunate needlestick injury. M.A. van Agtmael. British Medical Journal 1997;314:337.
  • Het maligne neuroleptica syndroom: wel of geen volledige antistollingsbehandeling? M.A. van Agtmael, P.N. van Harten. Ned Tijdschrift voor Geneeskunde 1992; 136,nr 38, 1870 1872.
  • Rapid identification of pathogens in blood cultures with a modified FISH assay. Peters RP, van Agtmael MA, Simoons-Smit AM, Danner SA, Vandenbroucke-Grauls CM, Savelkoul PH. J Clin Microbiol. 2006 Nov;44(11):4186-8.
  • Rise in HCV-incidence among men who have sex with men in Amsterdam: Evidence for sexual transmission of HCV . Thijs J.W. van de Laar, Akke K. van der Bij, Maria Prins, Sylvia M. Bruisten, Kees Brinkman, Jan van der Meer Henry de Vries,Jan-Willem Mulder, Michiel van Agtmael,Suzanne Jurriaans, Katja C. Wolthers  and Roel A. Coutinho. JID 2007.
  • Cutting edge: Rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection. van der Vliet HJ, van Vonderen MG, Molling JW, Bontkes HJ, Reijm M, Reiss P, van Agtmael MA, Danner SA, van den Eertwegh AJ, von Blomberg BM, Scheper RJ. J Immunol. 2006 Nov 1;177(9):5775-8.
  • Faster identification of pathogens in positive blood cultures by fluorescence in situ hybridization in routine practice. Peters RP, Savelkoul PH, Simoons-Smit AM, Danner SA, Vandenbroucke-Grauls CM, van Agtmael MA. J Clin Microbiol. 2006 Jan;44(1):119-23.
  • Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination. Bakker-Woudenberg IA, van Vianen W, van Soolingen D, Verbrugh HA, van Agtmael MA. Antimicrob Agents Chemother. 2005 Jun;49(6):2387-98.
  • Detection of bacterial DNA in blood samples from febrile patients: underestimated infection or emerging contamination? Peters RP, Mohammadi T, Vandenbroucke-Grauls CM, Danner SA, van Agtmael MA, Savelkoul PH. FEMS Immunol Med Microbiol. 2004 Oct 1;42(2):249-53.
  • The development of an immunoassay for the detection of artemisin in compounds in urine. T.A.Eggelte, M.A. van Agtmael, Thi Dan Vuong,C.J. van Boxtel. American Journal of Tropical Medicine and Hygiene 61(3), 1999, 449-456.
  • Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. M.A. van Agtmael, Shan Cheng-Qi , Jiao Xiu Qing,  R. Mull , C.J. van Boxtel. International Journal of Antimicrobial Agents  1999;12:151-158.
  • The Comparative Efficacy and Tolerability of CGP 56697 (artemether+lumefantrine) versus Halofantrine in the Treatment of Uncomplicated Falciparum Malaria in Travellers returning from the Tropics to the Netherlands and France. Michiel van Agtmael, Olivier Bouchaud, Denis Malvy, Jean Delmont, Martin Danis, Stéphane Barette,  Claude Gras, Jacques Bernard, Jean-Etienne Touze, Insa Gathmann  , Robert Mull and the CGP 56697 Study Group. International Journal of Antimicrobial Agents 1999;12: 159-169.
  • Grapefruit juice increases the bioavailability of artemether.  M.A. van Agtmael, V. Gupta, T.H. van der Wösten, J.-P. B. Rutten, C.J. van Boxtel. European Journal of Clinical Pharmacology  1999;55(5):405-410.
  • The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects. M.A. van Agtmael, V. Gupta, C.A.A. van der Graaf, C.J. van Boxtel Clinical Pharmacology and Therapeutics 1999;66:408-414.
  • Validation of an improved reversed-phase HPLC assay with reductive electrochemical detection for the determination of artemisin in derivatives in man M.A. van Agtmael, J.J. Butter, E.J.G. Portier, C.J. van Boxtel.Therapeutic Drug Monitoring 1998;20:109-116.
  • The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects. M.A. van Agtmael, C.A.A. van der Graaf, T.K. Dien, R.-P. Koopmans, C.J. van Boxtel. European Journal of Drug Metabolism and Pharmacokinetics 1998:23:3;429-436.
  • Some pharmacokinetic and -dynamic comparisons of artemisinin derivatives in man. C.J. van Boxtel, M.A. van Agtmael, P.J. de Vries, Tran Khac Dien, R.P. Koopmans, P.A. Kager. Japanese Journal of Tropical Medicine and Hygiene 1996:24:7;49-54.
  • Antibiotic induced endotoxin release in patients with gram negative urosepsis: a double blind study comparing imipenem and ceftazidime. Jan M. Prins, Michiel A. van Agtmael, Ed J. Kuijper, Sander J.H. van Deventer, Peter Speelman. The Journal of Infectious Diseases 1995;172 (September): 886 91.
  • Complete anticoagulation for treatment of neuroleptic malignant syndrome. P.N. van Harten, M.A. van Agtmael. The American Journal of Psychiatry. 152(7):1103   4, 1995 July.
  • Analysis of 81 cases of Acute Chest syndrome in Adults with Sickle Cell Disease. M.A. van Agtmael, J.D. Cheng, J.C. Nossent . West Indian Medical Journal 1993;42:18.
  • Prediction of Serum Theophylline Level using the Disease Factor Product. A Pilot Study. M.A. van Agtmael, C.C. Peck. West Indian Medical Journal 1992;41:34 35.


  • TNF-blocking drugs and infection; recommendations for daily practice. Jacobs JW, Creemers MC, van Agtmael MA, van de Laar MA, van der Poll T, Tak PP, Bijlsma JW. Ned Tijdschr Geneeskd. 2007 Mar 10;151(10):588-93.
  • Two HIV-positive men with anorectal lymphogranuloma venereum and hepatitis C: emerging sexually transmitted diseases. van Agtmael MA, Perenboom RM. Ned Tijdschr Geneeskd. 2004 Dec 18;148 (51):2547-50.
  • Altijd een echocardiogram bij een grampositieve bacteriëmie?Pim G.N.J. Mutsaers, Michiel A. van Agtmael. Ned Tijdschr Geneeskd. 2011;155:A4203.
  • Cranberries of co-trimoxazol om urineweginfecties te voorkómen. Michiel A van Agtmael
    Ned Tijdschr Geneeskd. 2011;155:A4047.
  • Transmissie van influenza in het vliegtuig . Yvonne W.S. Jauw en Michiel A. van Agtmael
    Ned Tijdschr Geneeskd. 2010;154:A2514.
  • Wel of geen dexamethason bij een bacteriële meningitis? Jessica de Vocht en Michiel A. van Agtmael. Ned Tijdschr Geneeskd. 2010;154:A2190.
  • Nieuwe, snelle urinetest voor chlamydia. Marielle Veldkamp en Michiel van Agtmael
    Ned Tijdschr Geneeskd. 2010;A1567.
  • Vaginale douche verhoogt het risico op soa's. Marije Bomers en Michiel van Agtmael
    Ned Tijdschr Geneeskd. 2009;153:A301.
  • Controle op het naleven van richtlijnen verkort opnameduur bij een pneumonie. W.F.W. Bierman en M.A. van Agtmael. Ned Tijdschr Geneeskd. 2008;152:652-3.
  • Het is veilig om bij ernstige pneumonie na 3 dagen te switchen van intraveneuze naar orale antibiotica. E.A. Bij de Vaate en M.A. van Agtmael. Ned Tijdschr Geneeskd. 2007;151:1651.
  • Elke 3 maanden switchen van HIV-therapie voorkomt falen. M.A. van Agtmael
    Ned Tijdschr Geneeskd. 2004;148:544.
  • Moeten wij griep gaan behandelen met een antiviraal middel? M.A. van Agtmael
    Ned Tijdschr Geneeskd. 2003;147:2192.

Book chapters

  • Acute Geneeskunde. LG Thijs, 7de herziene druk 2009. Hoofdstuk 22. Koorts. RJM Strack van Schijndel , MA van Agtmael, MAM de Backer.
  • Diagnostiek van alledaagse klachten, bouwstenen voor rationeel probleem oplossen. TOH de Jong, H de Vries, HGLM Grundmeijer, Bohn Stafleu van Loghum 3de herziene druk 2011. Hoofdstuk: Koorts bij volwassenen. H de Vries, M.A. van Agtmael, JF Bastiaans.
  • Drugs, Benefits and Risks: International Textbook of Clinical Pharmacology, C.J. van Boxtel, B. Santoso, I.R. Edwards (John Wiley &Sons, Ltd, 2de druk) Section III, Chapter 33A Treatment and prophylaxis of infectious diseases. Michiel A. van Agtmael,Tran Tinh Hien, Henry A. Verbrugh, Inge C. Gyssens en 33B Treatment of HIV/AIDS and of tuberculosis. Andrew D. Kambugu, Chris J. van Boxtel, Michiel A. van Agtmael
  • Medische Misvattingen, nieuwe inzichten in de geneeskundige praktijk, J.J.E. van Everdingen, C.J.E. Kaandorp (Bohn, Stafleu van Loghum, 2de druk) Hoofdstuk 9: De diagnose malaria stel je tijdens een koortspiek.
  • Geneesmiddelen in Nederland. L.Reijnders, M. Bouvy , H.Buurma, A.Vulto.(17de  editie, 2004) Hoofdstuk 41 Middelen tegen amoeben en malaria.


Clinical & pharmacological studies on artemether in the treatment of malaria (1999).

Academic activities


  • Member of Education subcommittee of EACPT


  • NVKF
  • NIV
  • NVMO
  • Advisory boards Farma
  • KNMP commission medicines


  • Course coordinator, Infection and Inflammation in Bachelor year 3, VUmc School of Medical Sciences
  • Tutor for Bachelor year 2 medical students, VUmc School of Medical Sciences
  • Workshops on therapy
  • Clinical bedside teaching
  • Teaching/coordinating in Pharmacotherapy/Medication Management
  • Research on education in therapeutic reasoning
  • Project supervisor Student-run clinic


  • Clinical student research fellowships in Dept of infectious diseases, Grooteschuur hospital  Capetown South Africa (Prof Marc Mendelson)
  • Ph D student Titus Msoka  studies on cardiovascular risk in HIV at Kilimanjaro Christian Medical Center, Moshi, Tanzania