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Professor of Physiology, Chair Department of Physiology

Jolanda van der Velden

Office 11 W 55

O/2 Building

Tel (+31) 0627339909

Email j.vandervelden@vumc.nl

Research focus:

Failure of the heart muscle caused by mutations in sarcomeric proteins in inherited cardiomyopathies

Jolanda van der Velden received a Master degree in Medical Biology at the University of Leiden in 1994 and her PhD in Physiology at the VU University in Amsterdam in 1998. She was appointed Assistant Professor at the Laboratory for Physiology of the VU University Medical Center in 2002. In 2012 she received a Professorship on "Cellular pathophysiology of cardiomyopathies" at the ICIN-Netherlands Heart Institute.
The main focus of the research group of Jolanda van der Velden (Physiology, VU University Medical Center) involves investigation of changes in myofilament protein composition and function, which contribute to impaired cardiomyocyte function in heart failure, and may be target for drug therapy. The research is characterized by a multi-disciplinary approach with strong interaction between fundamental and clinical research.
Since January 1st 2014 she is chair of Department of Physiology of the Vumc. From the 1st of May 2014 she is Director of the VUmc Cardiovascular Research Institute, ICaR-VU. She is recipient of an Innovational Research Incentives Scheme VENI award (2002) and an Innovational Research Incentives Scheme VIDI award (2010) from the Netherlands Organization of Scientific Research (NWO); she participated as principlal investigator in the EU-funded project Big-Heart: Bench-to-bedside Integrated approach to familial hypertrophic cardiomyopathy: to the heart of the disease. Recently, in collaboration with colleagues from the AMC, UMCU, UMCG and Erasmus MC she received a CVON (Cardiovasculair Onderzoek Nederland) grant , which will increase collaborative studies in the Netherlands on inherited cardiomyopathies.

Selection of recent publications

  1. van der Velden J, Ho CY, Tardiff J, Olivotto I, Knollmann BC, Carrier L. Research priorities in sarcomeric cardiomyopathies. Cardiovascular Research 2015;105:449-556.
    With editorial by G Hasenfuss. Sarcomeric cardiomyopathies: from bedside to bench and back.
  2. Sequeira V, Najafi A, McConnell M, Fowler ED, Bollen IAE, Wüst RCI, dos Remedios CG, Helmes M, White E, Stienen GJM, Tardiff JC, Kuster DWD, van der Velden J. Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness. Journal of Physiology 2015, in press.
  3. Wijnker PJM,* Li Y,* Zhang P, Foster DB, dos Remedios C, van Eyk JE, Stienen GJM, Murphy AM, van der Velden J. A novel phosphorylation site, serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. Journal of Molecular and Cellular Cardiology 2015;82:93-103.
  4. Najafi A, Schlossarek S, van Deel ED, van den Heuvel N, Güçlü A, Goebel M, Kuster DWD, Carrier L, van der Velden J. Sexual dimorphic response to exercise in hypertrophic cardiomyopathy- associated Mybpc3-targeted knock-in mice. Pflügers Archiv-European Journal of Physiology 2014, in press.
  5.  Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AMC, Christiaans I, Wilde AAM, dos Remedios C, Lammertsma AA, van Rossum AC, Stienen GJM, van Slegtenhorst M, Schinkel AF, Michels M, Ho CY, Poggesi C, van der Velden J. Gene-specific increase in energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations. Cardiovascular Research 2014; 103:248-57.
    With editorial by JS Ingwall. The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy

Ongoing research projects

2015-2020 Cardiovasculair Onderzoek Nederland (CVON) research grant 2015. Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches. Acronym: Dosis. Coordinators: Jolanda van der Velden, Bianca Brundel (VUmc) & Rudolf de Boer (UMCG). National consortium grant (VUmc, AMC, UMCG, UMCU, Erasmus MC).

2015-2018 NIH (National Institutes of Health) Research grant - National Heart,  Lung and Blood Institute. 'Molecular physiology of troponin I variants.'  Collaboration with Prof dr. AM Murphy (Johns Hopkins University  School of Medicine, Baltimore, USA).

2014-2016 Hartstichting/stichting Hartedroom 2013: Co-PI on 'Boosting chaperone networks to counteract juvenile DCM caused by chaperone mutations.' Collaboration with Harrie Kampinga & Bianca Brundel (UMCG).

2013-2017 Rembrandt Research grant 2013. Functional genomics to identify the pathomechanisms of human dilated cardiomyopathy caused by mutations in the giant sarcomeric protein titin. Collaboration with Yigal Pinto (AMC).

2012-2017 Cardiovasculair Onderzoek Nederland (CVON) research grant 2011. Approaching heart failure by translational research of RNA mechanism (ARENA). Principal investigator and work package leader. National coordinators: Yigal Pinto & Leon de Windt.

2010-2015 NWO VIDI grant - Innovational Research 2010. Sarcomeric dysfunction as a target for treatment in primary human cardiomyopathy.

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