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Bianca Brundel

Office 11W15

O/2 Building

Tel (+31) 0627339900

Email b.brundel@vumc.nl

Research focus:

Role of protein homeostasis and the protein quality control system underlying atrial fibrillation

Bianca Brundel is currently Established Investigator, funded by the Dutch Heart Foundation (2014-2019) and Consortium leader of HALT&REVERSE (collaboration with Natasja de Groot EMC; 2014-2019). She opened up new directions for research on protein homeostasis and the protein quality control system underlying atrial fibrillation with the development of a Drosophila model. She is founder of NYKEN BV (2009), a bio-pharmaceutical company to develop innovative therapies for the treatment of atrial fibrillation, using its proprietary platform of Heat Shock Factor activators ( www.nyken.com ).
Bianca Brundel is project leader, together with Prof. Dr. J. van der Velden of the CVON project 'Dosis' (2015-2019). This project aims to identify determinants for onset of inherited cardiomyopathy. Previously developed innovative experimental model systems, which were successfully utilized in atrial fibrillation and GWAS studies, will be exploited in inherited cardiomyopathy studies. Also the invention on the role of protein quality control system in atrial fibrillation will be expanded to other heart and vascular diseases. Brundel has collaborations with (inter)national top researchers (Stanley Nattel, Ivor Benjamin, Edward O'Brien, Rolf Bodmer). Bianca will spend one day per week at the VUmc, Bianca works since 2016 at the Physiology department

Selection of recent publications

  1. Duncker DJ, Bakkers J, Brundel BJJM, Robbins J, Tardiff JC, Carrier L. Animal- and In Silico Models for the study of Sarcomeric Cardiomyopathies. Cardiovasc Res. 2015 Apr;105(4):439-448.
  2. Meijering RAM, Henning RH, Brundel BJJM. Reviving the Protein Quality Control System: Therapeutic Target for Cardiac Disease in the Elderly. Trends Cardiovasc Med 2015 25(3):243-247.
  3. Zhang D, Wu CT, Qi XY, Meijering RAM, Hoogstra-Berends F, Deniz G, Durdu S, Akar R, Sibon OCM, Nattel S, Henning RM and Brundel BJJM. Activation of Histone Deacetylase-6 (HDAC6) induces contractile dysfunction through derailment of ?-tubulin proteostasis in experimental and human Atrial Fibrillation. Circulation, 2014; 129:346-58.
  4. Qi XY, Diness J.G., Brundel BJJM, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D, Grunnet M, and Nattel S. Role of Small-Conductance Calcium-Activated Potassium Channels in Atrial Electrophysiology and Fibrillation in the Dog. Circulation, 2014; 129:430-440.
  5. Den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM et al. Heart rate-associated loci and their effects on cardiac conduction and rhythm disorders- results from a GWAS in up to 181.171 individuals. Nature Genetics 2013; 45:621-31.
  6. Zhang D, Ke L, Mackovicova K, Der Want JJ, Sibon OC, Tanguay RM, Morrow G, Henning RH, Kampinga HH, Brundel BJJM: Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for AF. JMCC 2011; 51:381-389.

Ongoing research projects

2015-2020: CVON grant DOSIS: Determinants of susceptibility in inherited cardiomyopathy: towards novel therapeutic approaches. Project leaders: Prof. J. van der Velden and Dr. B. Brundel (VUmc)and with Prof. H. H. Kampinga (UMCG), Prof. Y. Pinto (AMC), Dr. J.P van Tintelen (UMCG) and Prof. R. de Boer (UMCG)

2014-present: Established investigator, Dutch Heart Foundation: REVersal of cardiomyocyte structural remodeling and Improvement of functional recoVEry in Atrial Fibrillation. REVIVE

2014-present: LSH grant. HSF1 activators lower cardiomyocyte damage: towards a novel therapeutic approach to reverse Atrial Fibrillation. HALT&REVERSE (Consortium leader)
 With: Dr. N. de Groot (EMC), Nyken BV, Dutch Heart Foundation

2014-present: Dutch Heart Foundation funded grant: Juvenile Cardiomyopathy. Boosting chaperone networks to counteract juvenile DCM caused by chaperone mutations. (co-PI)
 With: Prof. H. Kampinga (UMCG) and Prof. J. van der Velden (VUmc)

2014-present: Biobrug grant on pharmacokinetics and dynamics of HSP-boosting compounds
 With: Nyken BV

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