Betrokken en zorgvuldig - Kennis maakt ons beter

Organic Acids Mixture

In order to improve the performance of laboratories in organic acid measurements and harmonization of laboratory results, it is essential that control materials are available.

Following advice of the ERNDIM Advisory Board a mixture of organic acids was composed having - after reconstitution with 5 mL water – the following concentrations:

                                  

Mixture A

µMol/L

Mixture B

µMol/L

D,L-lactate                  

2000

glycolate

500

D,L-3-hydroxybutyrate

2000

3-hydroxyisovalerate

500

methylmalonate

2000

ethylmalonate

500

fumarate

500

glutarate

500

adipate

500

L-2-hydroxyglutarate

500

suberate

500

sebacate

500

malonate

500

D,L-pyroglutamate

2000

3-methylglutarate

500

(+/-)-mevalonolactone

500

3-methylglutaconate

500

orotate

500

2-ketoglutarate

500

butyrylglycine

100

isovalerylglycine

500

3-methylcrotonylglycine

100

D,L-2-methylbutyrylglycine

100

hexanoylglycine

100

tiglylglycine

100

N-acetyl-L-aspartate

500

suberylglycine

100

D-(+)-malate

500

propionylglycine

100

D,L-4-hydroxyphenyllactate

500

3-hydroxyglutarate

500

succinylacetone

200

4-hydroxybutyrate

400

thymine

100

 

The 2 sets of mixtures are provided as lyophilized products. After reconstitution, products should be processed as patient samples according to existing procedures for organic acid analysis.

 

print