Inflammation in the cardiovascular system
Inflammation of the cardiovascular system is a central denominator in cardiovascular disease. It not only is the cause of cardiovascular disease in general, but at the same time it is propagated by the disease itself and/or therapeutical intervention. As such inflammatory mediators form diagnostic and prognostic biomarkers for the disease process and therapeutical interventions.
We are studying this at the level of
- bloodvessels (venous bypass graft failure, aortic valve disease, wound healing, diabetes, pulmonary vasculature in PH)
- ischemia and/or myocarditis (infectious and non-infectious)
Our aims are to get insight in the pathophysiology of (cardiovascular, pulm. vascular) inflammation, to develop diagnostic and prognostic biomarkers (inflammatory mediators) end to develop biomarkers to evaluate new therapies.
Therefore we evaluate inflammatory mediators in cardiovascular and pulmonary vascular disease as putative new biomarkers in human and animal tissue banks, we study their mechanisms of binding and activation on/in endothelial cells, smooth muscle cells and cardiomyocytes and we evaluate inhibitors of these mediators as proof-of-principle in animal models.
Hans Niessen MD PhD - program leader
Christof Meischl MD PhD - academic staff
Frank van de Goot MD PhD - academic staff
Annemiek van Dijk MSc - PhD student
Paul Krijnen MD - PhD student
Koba Kupreishvili MSc - PhD student
Nynke Hahn MD - PhD student
Benno Naaikens - PhD student
Hier de tekst
Hier de tekst
Hier de tekst
Hier de tekst
Hier de tekst
Hier de tekst